Key messages
- L’obiettivo del presente studio è stato confrontare l’incidenza della psoriasi tra i pazienti, con una stratificazione in base alla categoria del body mass index (BMI) (normale, sottopeso, sovrappeso, obesità di classe 1 o 2/3).
- Il BMI influenza in maniera indipendente lo sviluppo della psoriasi. Sembra esserci un’associazione graduata tra il suo valore e il rischio di malattia.
Abstract
Background
Psoriasis has been linked to obesity, although data on the incidence of psoriasis according to body mass index (BMI) are limited.
Objective
To compare incidence of psoriasis among patients stratified by BMI category (normal or underweight, overweight, obese class 1, obese class 2/3).
Methods
Retrospective cohort analysis of a demographically heterogeneous sample of over 1.5 million patients in the United States between January 1, 2008 and September 9, 2019.
Results
Crude incidence of psoriasis per 10,000 person-years was 9.5 (95% confidence interval [CI], 9.1-10.0) among normal or underweight patients, 11.9 (95% CI, 11.4-12.4) among overweight patients, 14.2 (95% CI, 13.6-14.9) among obese class 1 patients, and 17.4 (95% CI, 16.6-18.2) among obese class 2/3 patients. Compared to patients with BMI < 25.0, those who were overweight (adjusted hazard ratio, 1.19; 95% CI, 1.12-1.27; p < 0,001), obese class 1 (adjusted hazard ratio, 1.43; CI, 1.34-1.53; p < 0,001) and obese class 2/3 (adjusted hazard ratio, 1.83; CI, 1.71-1.95; p < 0,001) significantly greater risks for developing psoriasis.
Limitations
Influence of obesity on psoriasis severity could not be measured.
Conclusion
BMI independently influences the development of psoriasis. There appears to be a graded association between BMI and risk of psoriasis.