TOPIC:
13 Ottobre 2022
Neslihan Demirel Öğüt, Sema Koç Yıldırım, Ece Erbağcı, et al.

Ixekizumab treatment in patients with moderate-to-severe plaque psoriasis in a real-world clinical setting

J Cosmet Dermatol. 2022 Jul 8. Online ahead of print
  • Obiettivo dello studio è stato analizzare i dati real-world sulla terapia con ixekizumab per valutarne l’efficacia e la sicurezza ed evidenziare i fattori che influenzano la risposta al trattamento.
  • Ixekizumab rappresenta un’opzione di trattamento sicura ed efficace per i pazienti con psoriasi moderata-severa.
  • L’obesità, sebbene influenzi la risposta iniziale al trattamento (fino alla 4a settimana), non altera la risposta globale oltre la 16ma settimana.
  • I pregressi trattamenti con biologici e il coinvolgimento di aree difficili da trattare sono fattori prognostici importanti per il raggiungimento di elevate risposte al PASI.

Abstract

Background
The efficacy and safety reports of ixekizumab for moderate-to-severe plaque psoriasis may vary between clinical trials and real-world studies.

Aim
To analyze the real-world data of ixekizumab therapy to evaluate its efficacy and safety and highlight the factors influencing the treatment response in the real-world scenario.

Patients/Methods
Data of 82 adult patients with moderate-to-severe chronic plaque psoriasis are included in this study. Psoriasis area severity index (PASI) 75/90/100 responses at 4, 16, 24, and 48 weeks were analyzed retrospectively from patient charts by examining demographic and clinical characteristics of the patients, especially their previous biologic experience, obesity, and involvement of hard-to-treat areas.

Results
PASI75, PASI90, and PASI100 responses were achieved in 92.4%, 86.1%, and 26.6% patients at week 16 and maintained till week 48 in 92.3%, 86.5%, and 17.3% patients. PASI90 responses in obese patients were significantly lower than non-obese patients at week 4 (33.3% vs. 69.6%, p = 0.042), but this difference was minimized by week 16 (82.4% vs. 90%, p = 0.405). PASI90 responses in biologic-naive patients were significantly higher than biologic-experienced patients at week 16 (p = 0.015). Involvement of hard-to-treat areas was negatively associated with PASI90 responses at week 16 (OR: 1591805.842; 95% CI: 1.223-2071404486740.201; p = 0.047).

Conclusions
Ixekizumab provides an effective and safe biologic treatment option to patients with moderate-to-severe plaque psoriasis. Obesity, though it affects the early treatment response (till week 4), does not upset the overall treatment response beyond week 16. Previous biologic exposure and involvement of hard-to-treat areas are important prognostic factors for achieving high PASI responses in psoriatic patients.

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