7 Giugno 2022
Cæcilie Bachdal Johansen, Alexander Egeberg, Espen Jimenez-Solem, Lone Skov, Simon Francis Thomsen

Association of maternal psoriasis and small for gestational age or preterm birth: a nationwide matched cohort study in 69.080 singleton infants

CED 2022;47(6):1115-1123
  • Obiettivo del presente studio è stato di indagare l’associazione tra psoriasi materna e rischio di neonati piccoli per l’età gestazionale e prematurità, sia globalmente che stratificati in base alla severità di malattia.
  • La psoriasi materna non è risultata associata ad un rischio aumentato di neonati piccoli per l’età gestazionale e prematurità. Il rischio di neonati piccoli per l’età gestazionale è risultato lievemente aumentato nelle donne con storia di psoriasi rispetto ai controlli, ma i neonati erano verosimilmente costituzionalmente piccoli, senza un rischio aumentato di morbidità e mortalità perinatali.


Women with certain inflammatory diseases have an increased risk of giving birth to infants who are small for gestational age (SGA) or preterm birth (PTB), with maternal disease activity being the most important risk factor. However, previous studies investigating an association between psoriasis and SGA are scarce and have shown conflicting results.

To investigate the association between maternal psoriasis and risk of SGA infants and PTB, respectively, both overall and stratified by psoriasis severity.

This was a nationwide register-based matched cohort study of women with psoriasis matched 1 : 10 to women without psoriasis on age at delivery, body mass index and smoking status and with their first singleton infant born during the period 2004-2017. Odds ratio (OR) and 95% CI were calculated in conditional logistic regression models adjusted for known risk factors.

From 516 063 deliveries, we identified 6282 women with psoriasis and 62.798 matched women without psoriasis. The risk of SGA and PTB was similar in women with psoriasis and matched controls: adjusted OR (aOR) = 1.07 (95% CI 0.98-1.17) and aOR = 1.05 (95% CI 0.93-1.19), respectively. The risk of term SGA was increased in women with psoriasis (aOR 1.11; 95% CI 1.01-1.22) compared with matched controls.

Maternal psoriasis was not associated with increased risk of SGA or PTB. Risk of term SGA was slightly increased in women with a history of psoriasis compared with matched controls, however; these infants are likely to be constitutionally small with no increased risk of perinatal morbidity and mortality.

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