26 Aprile 2022
J Liu, A Thatiparthi, A Martin, J J Wu

Association between psoriasis and thyroid dysfunction among US adults in the 2009-2014 National Health and Nutrition Examination Survey

J Am Acad Dermatol. 2022 Apr;86(4):897-899

Key messages

  • Evidenze emergenti sostengono l’associazione tra psoriasi e molteplici malattie autoimmuni, tra cui la malattia di Graves e la tiroidite di Hashimoto.
  • Il presente studio ha avuto come obiettivo quello di determinare la possibile associazione tra psoriasi e patologia tiroidea nei pazienti adulti utilizzando i dati del National Health and Nutrition Examination Survey (2009-2014), un database nazionale di informazioni sanitarie della popolazione generale degli Stati Uniti d’America.
  • È emerso che i pazienti con psoriasi hanno un rischio aumentato di patologia tiroidea.


Emerging evidence supports the association of psoriasis with several autoimmune diseases, including Graves’ disease and Hashimoto thyroiditis. However, the association between psoriasis and thyroid disease remains inconclusive in the US population. This study sought to determine whether psoriasis is associated with an increased risk of thyroid disease in adults using the 2009-2014 National Health and Nutrition Examination Survey, a nationally representative database of health information of the general population in the United States.

The results from our large-scale US population-based study may confirm the findings from a nationwide cohort study from Taiwan. Although the exact mechanism of association remains unknown, several studies have implicated the role of TH-1 cell-mediated inflammation in the immunopathogenesis of psoriasis and autoimmune thyroid disease. Several genes, including protein tyrosine phosphate nonreceptor alleles and a locus on 4q27, have also been found to be significantly associated with psoriatic and thyroid disease. Patients aged ≥40 years may be particularly susceptible, as one case-control study found a higher prevalence of anti–thyroid peroxidase antibody seropositivity in psoriasis patients with age of onset at diagnosis ≥40 years. In conclusion, the present study illustrates that US patients with psoriasis have an increased risk of having thyroid disease. Further large cohort studies are warranted to characterize the temporality between psoriasis diagnosis, psoriatic arthritis, and the onset of thyroid dysfunction.

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