26 Aprile 2022
C Ryan, L Guenther, P Foley, J Weisman, R T Burge, G Gallo, K See, M McKean-Matthews, C C Bertram, J F Merola

Ixekizumab provides persistent improvements in health-related quality of life and the sexual impact associated with moderate-to-severe genital psoriasis in adult patients during a 52-week, randomised, placebo-controlled, phase 3 clinical trial

J Eur Acad Dermatol Venereol. 2022 Apr;36(4):e277-e279

Key messages

  • La psoriasi genitale è spesso associata ad un significativo impatto sulla health-related quality of life (HRQoL), con una maggiore compromissione della salute sessuale rispetto alle forme di malattia senza coinvolgimento genitale. Tale forma è spesso sottodiagnosticata e sottotrattata.
  • I risultati del presente studio mostrano che i pazienti trattati con ixekizumab hanno raggiunto miglioramenti clinicamente significativi dei sintomi della psoriasi genitale, della HRQoL e dell’impatto della malattia sulla vita sessuale, che sono stati mantenuti fino a 1 anno.


Genital psoriasis (GenPs) has been reported in up to 63% of patients with psoriasis. It is often associated with significant impairment of health-related quality of life (HRQoL), including a significantly greater impact on sexual health than psoriasis with no genital involvement. Despite its prevalence and burden, GenPs is often underdiagnosed and undertreated.
Ixekizumab (IXE), a high-affinity monoclonal antibody selectively targeting interleukin-17A (IL-17A), is the only United States Food and Drug Administration-approved treatment for patients with moderate-to-severe plaque psoriasis that includes labelling information about successful treatment of patients with genital involvement.6 In the IXORA-Q trial, IXE provided significant improvements in HRQoL and in the sexual impact of GenPs following 12 weeks of treatment.7, 8 Here, we report the persistence of these improvements through 52 weeks.

Our results suggest IXE-treated patients achieved significant clinical improvements in GenPs symptoms, HRQoL, and the sexual impact of GenPs that persisted for up to 1 year, supporting the previous results of the IXORA-Q study and IXE as an efficacious treatment option for moderate-to-severe GenPs.

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