- Non è ancora noto se lo stile di vita sia associato al rischio di psoriasi in presenza di differenti livelli di rischio genetico.
- Il presente studio si basa sui dati di 500.000 partecipanti della UK Biobank e il rischio genetico è stato categorizzato in basso, intermedio ed elevato.
- I fattori relativi allo stile di vita sembrano essere predittivi del rischio di psoriasi, indipendenti dal rischio genetico, con un impatto relativo maggiore.
Abstract
Background
Whether the lifestyle is associated with the risk of psoriasis in the presence of different genetic risk levels remains unknown.
Objective
To examine the gene-behavior interaction in association with incident psoriasis.
Methods
This study is based on the data from the UK Biobank, which recruited 500,000 participants. Genetic risk was categorized into low, intermediate, and high groups. The lifestyle score comprised the body mass index, smoking, physical activity, and diet and was also categorized into the ideal, intermediate, and poor groups. Within each genetic risk group, the risks of incident psoriasis associated with each lifestyle level were investigated and compared with the low genetic risk and ideal lifestyle group.
Results
Compared with the low genetic risk and ideal lifestyle group, the poor lifestyle and high genetic risk group was associated with a hazard ratio of up to 4.625 (95% confidence interval [CI], 2.920-7.348) for psoriasis. There was no interaction between genetic risk and lifestyle. The population attributable fractions of lifestyle and genetic risk were 32.2% (95% CI, 25.1%-38.6%) and 13.0% (95% CI, 3.2%-21.8%), respectively.
Limitations
No verification in other independently ascertained populations.
Conclusions
Lifestyle factors are predictive of the risk of incident psoriasis independent of genetic risk, and the relative impact of lifestyle factors was greater than that of genetic risk.