- La psoriasi pustolosa generalizzata è una patologia rara e ci sono pochi studi relativi al trattamento e agli obiettivi terapeutici su grandi gruppi di pazienti.
- Nel presente studio i farmaci biologici hanno mostrato risultati favorevoli rispetto agli altri trattamenti.
Abstract
Background
Because generalized pustular psoriasis (GPP) is rare, there are few studies reporting treatments and outcomes for large numbers of patients.
Objective
To report treatments and outcomes in a large cohort of patients hospitalized with GPP.
Methods
Using a Japanese national inpatient database, we identified 1516 patients with GPP who required hospitalization between July 2010 and March 2019. We categorized patients into 3 medication groups: biologics (294 patients), oral agents without biologics (948 patients), and systemic corticosteroids only (274 patients). We investigated their characteristics, treatments, and outcomes.
Results
Mean age was 66 years (interquartile range: 52-77 years). Fifty patients (3.3%) were admitted to the intensive care unit, 125 (8.2%) required blood pressure support, and 63 (4.2%) died. Patients who received biologics were younger and had fewer comorbidities. In-hospital mortality was lower in the biologics group (1.0% [biologics group] vs 3.7% [oral-agents group] vs 9.1% [corticosteroids-only group]; p <.001) as was morbidity (5.4% vs 8.2% vs 12%, respectively; p = .02). Among those who received biologics, IL-17 inhibitor use increased over time, with in-hospital mortality and morbidity comparable to those of tumor necrosis factor inhibitors.
Limitations
Retrospective study design. Some patients received multiple medications.
Conclusion
Biologic treatments showed favorable outcomes compared with other treatments.